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Maturity-onset diabetes of the young ( MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. [1] Along with neonatal diabetes, MODY is a form of the conditions known as monogenic diabetes.
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Latent autoimmune diabetes in adults (LADA) is a heterogeneous subtype of diabetes characterized by islet cell destruction mediated by islet autoimmunity and insulin resistance. Metabolic syndrome (MetS) is a state in which many risk factors for metabolic and cardiovascular diseases accumulate in an individual.
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Maturity-onset diabetes of the young (MODY) is a non-insulin-dependent form of diabetes mellitus that is usually diagnosed in young adulthood. MODY is most often an autosomal dominant disease.
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In 1974, Tattersall and Fajans coined the term mature onset diabetes of the young (MODY). [1] MODY is the most common form of monogenic diabetes and exhibits autosomal dominant inheritance. Patients with this form of diabetes can sometimes be mistaken for having either type 1 diabetes (DM1) or type 2 diabetes mellitus (DM2).
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The study of asymptomatic diabetes in young people took a new direction in 1958 when I became aware of a 70-year-old male patient who was diagnosed with diabetes at the age of 41 years ( Supplementary Fig. 1, individual III-5). He was blind from diabetic retinopathy at the age of 61 years and had an amputation for peripheral vascular disease.
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Maturity-onset diabetes of the young (MODY), the historic term for some forms of monogenic diabetes, is a collection of inherited disorders of non-autoimmune diabetes mellitus (antibody-negative) that present at a young age of onset. The prevalence is estimated to be 1/10 000 in adults and 1/23 000 in children, although the prevalence of MODY.